Sputum viscosity and pulmonary function in cystic fibrosis.

Macrorheology of cystic fibrosis, chronic obstructive pulmonary disease & normal sputum

BACKGROUND Prior microrheologic assessments of selected, microlitre plugs of cystic fibrosis (CF) sputum suggest no intrinsic rheologic abnormality. However, such analyses may not be representative of CF sputum as a whole. We therefore reassessed this question using whole sputum macrorheology. Additionally, we wished to further explore the relationships between sputum rheology, inflammation and...

Restricted pulmonary function in cystic fibrosis.

Some patients with cystic fibrosis have reduced pulmonary volumes, indicating a restrictive pattern of pulmonary disease. We identified ten patients with pulmonary functional evidence of restriction among 158 patients with cystic fibrosis followed at the University of California San Diego Medical Center in 1984 and 1985. We characterized the radiographic, pulmonary functional, and clinical char...

Mucus, phlegm, and sputum in cystic fibrosis.

Although some clinicians still believe that cystic fibrosis (CF) lung disease is largely due to hypersecretion of very viscous mucus, it has never been demonstrated that there is mucus hypersecretion in CF and it is clear that there is almost no intact mucin (the principal polymeric component of normal mucus) in CF sputum. CF sputum has lower viscosity when compared to asthma or bronchitis sput...

Influence of mist tent therapy on sputum viscosity and water content in cystic fibrosis.

Sputum viscosity and postoperative pulmonary atelectasis.

The relationship between changes in the viscosity of sputum and the development of pulmonary atelectasis has been discussed.15 The fibers found in sputum which appear to be responsible for the viscosity are